Model-based Modified OGTT Insulin Sensitivity Test Design
نویسندگان
چکیده
منابع مشابه
Insulin secretion and insulin sensitivity on the oral glucose tolerance test (OGTT) in middle-aged Japanese.
The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean BMI 23.9±3.2 kg/m(2)) underwent an oral glucose tolerance test (OGTT). Of thes...
متن کاملOGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself.
Insulin resistance is an important risk factor for diabetes and other diseases. It has been important to estimate insulin resistance in epidemiological and genetic studies involving significant number of individuals. Complex and invasive protocols are impractical. Therefore, insulin sensitivity indices based on the oral glucose-tolerance test (OGTT) have been introduced. The aim of the present ...
متن کاملDesign and clinical pilot testing of the model-based dynamic insulin sensitivity and secretion test (DISST).
BACKGROUND Insulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes. This article presents pilot study results of the dynamic insulin sensitivity and secretion test (DISST), a high-resolution, low-intensity test to diagnose insulin sensitivity (IS) and characterize pancreatic insulin secretion in response to a (small) glucose challenge. This pilot study examines th...
متن کاملDifferences in Insulin Sensitivity and Secretory Capacity Based on OGTT in Subjects with Impaired Glucose Regulation
BACKGROUND This study examined whether defects in insulin secretion contribute to the development and progression of type 2 diabetes mellitus (T2DM). METHODS Plasma insulin and glucose were measured after a glucose tolerance test to calculate the insulinogenic index (IGI) and the HOMA-IR Homeostasis model assessment of insulin resistance in subjects with normal glucose tolerance (NGT), predia...
متن کاملInsulin and C-peptide secretion and kinetics in humans: direct and model-based measurements during OGTT.
To directly evaluate prehepatic secretion of pancreatic hormones during a 3-h oral glucose tolerance test (OGTT), we measured insulin and C-peptide in six healthy control, six obese, and six type 2 diabetic subjects in the femoral artery and hepatic vein by means of the hepatic catheterization technique. Hypersecretion in obesity was confirmed (309 +/- 66 nmol in obese vs. 117 +/- 22 in control...
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ژورنال
عنوان ژورنال: IFAC-PapersOnLine
سال: 2018
ISSN: 2405-8963
DOI: 10.1016/j.ifacol.2018.11.662